Masterpiece meaning. The meaning of MASTERPIECE is a work done with extraordinary skill; especially : a supreme intellectual or artistic achievement. How to use masterpiece in a sentence. See examples of masterpiece used in a sentence. a consummate example of skill or excellence of any kind: The chef 's cake was a masterpiece. anything done with masterly skill: a masterpiece of improvisation. An artist or writer is generally capable of creating only one masterpiece in her lifetime, if she makes a masterpiece at all. 1. Her work is a masterpiece of (= an excellent example of) simplicity. 'Man's Fate,' translated into sixteen languages, is probably his masterpiece. mas•ter•piece (mas′ tər pēs′, mä′ stər-), n. suehb xgvefsi imd ndrdrvat tumv pbva lbqbnu bhotss gmbor zhoh